In Vitro Activity of Piperacillin against 497 Gram Negative Bacilli Isolated ' from Blood Cultures

نویسندگان

  • Thira Sirisanthana
  • Prasit Tharavichitkul
چکیده

Agar dilution sensitivity tests to piperacillin were performed on 497 strains of gram ne­ gative bacilli isolated from blood culture of patients admitted to Maharaj Nakom Chiang Mai Hos­ pital. Piperacillin was found to have significant activity against Pseudomonas aeruginosa, Aero­ monos spp and Enterobacter spp. A substantial proportion of Escherichia coli, Klebsiella pneumo­ niae and Acinetobacter anitratus were not inhibited by the antibiotic at achievable concentrations. The resistant strains probably produced beta-Iactamases, to which piperacillin is susceptible. ..., , .1 .... , ,<II '" 0404 'v v t! l1fNtlfJ lJ1~"llfimVi lJ\UU)~1l~U'6~'U6~ piperacillin \JI6l')f6lltJfllll1UllHllll~fl1'UatJ 497 "lUVilJfi 04," ' ' '' . <II <II nuun ~;)lflfll1lVil~l')f6;)lflla6~ 1 11..1 4 .1 ...... 1 . ,.lI 4 4 , ~ J11fl11t1flltlu1tatl1iIll'Vt U\1lU)~t1~tUH'UtHpiperacillin 9Hll'lltlUUfltll1tltl1 ~UtI~ ., ••Yo ,~ 1 II .lI... 11.'1 1 'i 4 1 ' mueu 497 altlnU1itlUtlfl ~;)lflfl1l1'Vtltl'lltl;)lfllatl~'Utl~HultlU IH'VttlllJlall\111l'llUflll'lltl~ \111 ...... ",'..... ,l .• piperacillln IItJ1tatl1iIl1'Vt~91tll'lltlPBeUdomonas aeruganosa, Aeromonas spp. uat Enterobacter spp. UA1~tl Escherichia coli, Klebsiella pneumoniae uat Acinetobacter anitratus ~tl9l11flU .lI .lI ~ .lI , .; II be I ~ ..I • "II" 1 II ~tltJ1l!~ 1'lltltl~tltlll\1alUfl~allllHla1H taactamases 'II~J11altl piperacr 10 ~ rently available penicillins. 1,2 Because it inhibits INTRODUcrION many Pseudomonas aeruginosa strains in low con­ Although much attention has been focused on centration and because of its useful activity against the new cephalosporin-class antibiotics, there has also Klebsiella pneumoniae, piperacillin may be used in been progress made over the last few years in develop­ therapeutic situations where carbenicillin and ticar­ ing new, broad-spectrum., semisynthetic penicillins, cillin are presently used. The object of this study was namely azlocillin, mezlocillin and piperacillin. Pipera­ to assess the future usefulness of this antibiotic in cillin has been registered with the Royal Thai Minist­ septicemic patients at Maharaj Nakorn Chiang Mai ry of Public Health and will be marketed in June, Hospital, and to identify possible limitation to its use. 1985. In vitro studies with piperacillin have shown it to have a wide antibacterial spectrum and to be more MATERIALS AND METHODS active against many gram negative organisms than curAgar dilution sensitivity tests to piperacillin "'Departments of Medicine and "''''Microbiology, Faculty of Medicine, were perfonned on 497 strains of gram negative bacil­ ChiangMai University. li. Identification of the species of these bacilli was

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تاریخ انتشار 2008